Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction.

ABSTRACT:

Background

Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their production and recruitment to the injured heart are unclear.

Methods

Using a mouse model of the permanent ligation of the left anterior descending artery and flow cytometry, we first characterized the temporal and spatial effects of MI on different myeloid cell types. We next performed global transcriptome analysis of different cardiac cell types within the infarct to identify the drivers of the acute inflammatory response and the underlying signaling pathways. Using a combination of genetic and pharmacological strategies, we identified the sequelae of events that led to MI-induced myelopoiesis. Cardiac function was assess

SUBMITTER: Sreejit G 

PROVIDER: S-EPMC7122461 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature