Chemosensory modulation of neural circuits for sodium appetite.

ABSTRACT: Sodium is the main cation in the extracellular fluid and it regulates various physiological functions. Depletion of sodium in the body increases the hedonic value of sodium taste, which drives animals towards sodium consumption^1,2. By contrast, oral sodium detection rapidly quenches sodium appetite^3,4, suggesting that taste signals have a central role in sodium appetite and its satiation. Nevertheless, the neural mechanisms of chemosensory-based appetite regulation remain poorly understood. Here we identify genetically defined neural circuits in mice that control sodium intake by integrating chemosensory and internal depletion signals. We show that a subset of excitatory neurons in the pre-locus coeruleus express prodynorphin, and that these neurons are a critical neu

SUBMITTER: Lee S 

PROVIDER: S-EPMC7122814 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature