TLR5 Activation Exacerbates Airway Inflammation in Asthma.

ABSTRACT:

Introduction

Innate immune activation through exposure to indoor and outdoor pollutants is emerging as an important determinant of asthma severity. For example, household levels of the bacterial product lipopolysaccharide (LPS) are associated with increased asthma severity. We hypothesized that activation of the innate immune receptor TLR5 by its bacterial ligand flagellin will exacerbate airway inflammation and asthma symptoms.

Methods

We determined the effect of flagellin co-exposure with ovalbumin in a murine model of allergic asthma. We evaluated the presence of flagellin activity in house dust of asthma patients. Finally, we analyzed the association of a dominant-negative polymorphism in TLR5 (rs5744168) with asthma symptoms in patients with asthma.

Results

We sh

SUBMITTER: Whitehead GS 

PROVIDER: S-EPMC7123460 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature