Microphysiological heart-liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery.

ABSTRACT: Body-on-a-chip in vitro systems are a promising technology that aims to increase the predictive power of drug efficacy and toxicity in humans when compared to traditional animal models. Here, we developed a new heart-liver body-on-a-chip system with a skin surrogate to assess the toxicity of drugs that are topically administered. In order to test the utility of the system, diclofenac, ketoconazole, hydrocortisone and acetaminophen were applied topically through a synthetic skin surrogate (Strat-M membrane) and the toxicity results were compared to those of acute drug exposure from systemically applying the compounds. The heart-liver system was successful in predicting the effects for both cardiac and liver functions changes due to the compounds. The difference in the concentrations of drug

SUBMITTER: Pires de Mello CP 

PROVIDER: S-EPMC7123528 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature