Gasdermin E suppresses tumour growth by activating anti-tumour immunity.

ABSTRACT: Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)¹. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss²-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-expressing cells^3-5. GSDME expression is suppressed in many cancers, and reduced GSDME levels are associated with decreased survival as a result of breast cancer^2,6, suggesting that GSDME might be a tumour suppressor. Here we show that 20 of 22 tested cancer-associated GSDME mutations reduce GSDME function. In mice, knocking out Gsdme in GSDME-expressing tumours enhances, whereas ectopic expression in Gsdme-repressed tumours inhibits,

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7123794 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature