Long-term NO₂ exposures and cause-specific mortality in American older adults.

ABSTRACT:

Background

The impact of long-term exposure to nitrogen dioxide (NO₂) on cause-specific mortality is poorly understood.

Objective

To assess mortality risks associated with long-term NO₂ exposure and evaluate confounding of this association.

Methods

We examined the association between 12-month moving average NO₂ exposure and cause-specific mortality in 14.1 million US Medicare beneficiaries between 2000 and 2008. Associations were examined using age, gender, and race-stratified and state-adjusted Poisson regression models. We assessed the potential for confounding by PM_2.5 and behavioral covariates and unmeasured confounding by decomposing NO₂ into its spatial and spatio-temporal components.

Results

We found

SUBMITTER: Eum KD 

PROVIDER: S-EPMC7123874 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature