Metabolomic profiles associated with all-cause mortality in the Women's Health Initiative.

ABSTRACT:

Background

Metabolomics profiling has shown promise in elucidating the biological pathways underpinning mortality, but there are limited data in female populations.

Methods

We applied a liquid chromatography-tandem mass spectrometry metabolomics platform to EDTA-plasma to measure 470 metabolites at baseline in a discovery set of 943 postmenopausal women (including 417 incident deaths, median time to death of 10.6 years) with validation in an independent set of 1355 postmenopausal women (including 685 deaths, median time to death of 9.1 years) in the Women's Health Initiative.

Results

Eight new metabolites were discovered to be associated with all-cause mortality. Findings included protective effects of increased levels of three amino acids (asparagine, homoarginine an

SUBMITTER: Balasubramanian R 

PROVIDER: S-EPMC7124492 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature