The role of cardiovascular disease in the relationship between air pollution and incident dementia: a population-based cohort study.

ABSTRACT:

Background

Evidence suggests a link between air pollution and dementia. Cardiovascular disease (CVD) may be a potential determinant of dementia. This motivated us to quantify the contribution of CVD to the association between air pollution and dementia.

Methods

A cohort of Canadian-born residents of Ontario, who participated in the 1996-2003 Canadian Community Health Surveys, was followed through 2013 or until dementia diagnosis. Exposure to nitrogen dioxide (NO2) and fine particulate matter (PM2.5) was estimated with a 3-year average and 5-year lag before dementia diagnosis. Incident CVD was evaluated as a mediator. We used multi-level Cox proportional and Aalen additive hazard regression models, adjusting for individual- and neighbourhood-level risk factors to estimate ass

SUBMITTER: Ilango SD 

PROVIDER: S-EPMC7124495 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature