A genetics-led approach defines the drug target landscape of 30 immune-related traits.

ABSTRACT: Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of efficacy on early target selection¹. Drug targets with genetic support are more likely to be therapeutically valid^2,3, but the translational use of genome-scale data such as from genome-wide association studies for drug target discovery in complex diseases remains challenging^4-6. Here, we show that integration of functional genomic and immune-related annotations, together with knowledge of network connectivity, maximizes the informativeness of genetics for target validation, defining the target prioritization landscape for 30 immune traits at the gene and pathway level. We demonstrate how our genetics-led drug target prioritization approach (the priority index

SUBMITTER: Fang H 

PROVIDER: S-EPMC7124888 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature