Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.

ABSTRACT: Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays functional roles in signaling remains unexplored. To determine if structure informs function, we generated mice with zG-specific expression of GCaMP3 and imaged zG cells within their native rosette structure. Here we demonstrate that within the rosette, angiotensin II evokes periodic Ca_v3-dependent calcium events that form bursts that are stereotypic in form. Our data reveal a critical role for angiotensin II in regulating burst occurrence, and a multifunctional role for the rosette structure in activity-prolongation and coordination. Combin

SUBMITTER: Guagliardo NA 

PROVIDER: S-EPMC7125102 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature