Miro2 tethers the ER to mitochondria to promote mitochondrial fusion in tobacco leaf epidermal cells.

ABSTRACT: Mitochondria are highly pleomorphic, undergoing rounds of fission and fusion. Mitochondria are essential for energy conversion, with fusion favouring higher energy demand. Unlike fission, the molecular components involved in mitochondrial fusion in plants are unknown. Here, we show a role for the GTPase Miro2 in mitochondria interaction with the ER and its impacts on mitochondria fusion and motility. Mutations in AtMiro2's GTPase domain indicate that the active variant results in larger, fewer mitochondria which are attached more readily to the ER when compared with the inactive variant. These results are contrary to those in metazoans where Miro predominantly controls mitochondrial motility, with additional GTPases affecting fusion. Synthetically controlling mitochondrial fusion rates cou

SUBMITTER: White RR 

PROVIDER: S-EPMC7125145 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature