Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus.

ABSTRACT: LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In systemic lupus erythematosus (SLE), LL37 also triggers IFN-I in pDCs and is target of pathogenic autoantibodies. However, whether LL37 activates T-cells in SLE and how the latter differ from psoriasis LL37-specific T-cells is unknown. Here we found that 45% SLE patients had circulating T-cells strongly responding to LL37, which correlate with anti-LL37 antibodies/disease activity. In contrast to psoriatic Th17-cells, these LL37-specific SLE T-cells displayed a T-follicular helper-(T_FH)-like phenotype, with CXCR5/Bcl-6 and IL-21 expression, implicating

SUBMITTER: Lande R 

PROVIDER: S-EPMC7125190 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature