Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.
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ABSTRACT:
SUBMITTER: Bonfanti AP
PROVIDER: S-EPMC7125223 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.
Bonfanti Amanda Pires AP Barreto Natália N Munhoz Jaqueline J Caballero Marcus M Cordeiro Gabriel G Rocha-E-Silva Thomaz T Sutti Rafael R Moura Fernanda F Brunetto Sérgio S Ramos Celso Dario CD Thomé Rodolfo R Verinaud Liana L Rapôso Catarina C
Scientific reports 20200403 1
Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in glioblastoma (GB) cell lines. In the present work, the effects of PnV on tumor development were established in vivo using a xenogeneic model. Human GB (NG97, the most responsive line in the previous study) cells were inoculated (s.c.) on the back of ...[more]
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