High rates of aneuploidy, mosaicism and abnormal morphokinetic development in cases with low sperm concentration.

ABSTRACT:

Purpose

The aim of our study was to evaluate the impact of severe male infertility (SMF) on the chromosomal status of embryos and any possible correlation between chromosomal status and embryo morphokinetics in younger women using data obtained from comprehensive preimplantation genetic tests.

Methods

The trial was conducted in an ART and Reproductive Genetics Centre between 2011 and 2018. A total of 326 cycles in cases with SMF where the female partner's age was ≤ 35 years were evaluated. SMF is defined as sperm concentration below 5 mil/ml (million per milliliter) and divided into three subgroups according to sperm concentrations: 1-5 mil/ml, < 1mil/ml and testicular sperm. The control group of 190 cycles had normal sperm parameters.

Results

Significantly lower chro

SUBMITTER: Kahraman S 

PROVIDER: S-EPMC7125256 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature