A tale of two studies: now is no longer the best of times for preimplantation genetic testing for aneuploidy (PGT-A).

ABSTRACT: Preimplantation genetic testing for aneuploidy (PGT-A) does not create normal embryos, but selecting a viable embryo for a fresh transfer has the potential to deliver an extra effect for live birth from a stimulated cycle by evading the attrition associated with embryo cryopreservation. Improved genetic tests are now available for selecting viable embryos; however, current embryo cryopreservation techniques also have a superior survival rate, which means it is now possible to transfer most morphologically suitable embryos from a stimulated cycle one at a time. The cumulative live birth rate from a stimulated cycle is now unlikely to be superior compared with morphological assessment alone, with any benefit likely to be associated with a reduction in the risk of miscarriage and the time to

SUBMITTER: Scriven PN 

PROVIDER: S-EPMC7125274 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature