Variations in chromosomal aneuploidy rates in IVF blastocysts and early spontaneous abortion chorionic villi.

ABSTRACT:

Purpose

To compare chromosomal aberrations and aneuploidy features in (i) blastocysts following intracytoplasmic sperm injection (ICSI) and trophectoderm (TE) biopsy using preimplantation genetic screening (PGS) and (ii) early spontaneous abortion chorionic villus biopsies (SA-CVB) using single-nucleotide polymorphism (SNP) array detection.

Methods

We retrospectively reviewed the data for 1014 TEs from 220 PGS cycles and 1724 SA-CVBs originating from naturally pregnant couples and patients undergoing assisted reproductive technology (ART) during 2017 to 2018. SNP array was applied in both PGS and SA-CVBs detection. Aberrations were defined, and the frequency and ratio of each chromosome aberration were compared between the two groups.

Results

There were more abnormali

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7125276 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature