Radiation-induced changes to bone composition extend beyond periosteal bone.

ABSTRACT:

Background

Cancer patients receiving radiotherapy for soft tissue sarcomas are often at risk of post-irradiation (post-RTx) bone fragility fractures, but our understanding of factors controlling radiation-induced bone injury is limited. Previous studies have evaluated post-RTx changes to cortical bone composition in the periosteum of irradiated tibiae, but have not evaluated effects of irradiation in deeper tissues, such as endosteal or mid-cortical bone, and whether there are differential spatial effects of irradiation. In this study, we hypothesize that post-RTx changes to cortical bone composition are greater in endosteal compared to mid-cortical or periosteal bone.

Methods

A pre-clinical mouse model of limited field hindlimb irradiation was used to evaluate spatial and t

SUBMITTER: Mandair GS 

PROVIDER: S-EPMC7125315 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature