Clinical relationship between anemia and atrial fibrillation recurrence after catheter ablation without genetic background.

ABSTRACT:

Background

Anemia is a known adverse prognostic factor among patients with cardiovascular diseases. We investigated whether the hemoglobin level was associated with the rhythm outcome after atrial fibrillation (AF) catheter ablation (AFCA).

Methods

We included 2627 patients who underwent AFCA and a guidelines-based rhythm follow-up (age 58 ± 10.9 years, 73% men, 30.6% with persistent AF), and evaluated the association of pre-AFCA anemia (haemoglobin <13 g/dL in men and <12 g/dL in women) and rhythm outcomes. We studied the mechanistic relationship between anemia and AF recurrence using a Mendelian randomization analysis (1775 subjects with genome-wide association study) after reviewing already proven 12 hemoglobin-associated genetic polymorphisms.

Results

The body mas

SUBMITTER: Kim M 

PROVIDER: S-EPMC7125353 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature