Improved drug carriage and protective potential against Cisplatin-induced toxicity using Boldine-loaded PLGA nanoparticles.

ABSTRACT:

Background

Cisplatin is a widely-used potent anti-cancer drug having severe side-effects precluding its sustained use.

Objectives

Poly (lactide-co-glycolide) (PLGA)-nanoparticles loaded Boldine, an antioxidant ingredient of ethanolic extract of Boldo plant (Peumus boldus) was tested in cancer mice model, Mus musculus to examine if it could reduce unwanted Cisplatin-induced toxicity in normal tissue.

Material and methods

Nano-encapsulation of Boldine was done by following the standardized solvent displacement method. Physico-chemical characterization of PLGA-encapsulated nano-Boldine (NBol) was accomplished through analyses of various spectroscopic techniques. Status of major antioxidant enzymes, functional markers, and lipid peroxidation (LPO) was also determined in c

SUBMITTER: Mondal J 

PROVIDER: S-EPMC7125378 | biostudies-literature | 2020 Jan - Mar

REPOSITORIES: biostudies-literature