Punica granatum improves renal function in gentamicin-induced nephropathy in rats via attenuation of oxidative stress.

ABSTRACT: BACKGROUND:Gentamicin is widely used as an antibiotic for the treatment of gram negative infections. Evidences indicates that oxidative stress is involved in gentamicin-induced nephrotoxicity. In Ayurvedic medicine, Punica granatum Linn. is considered as 'a pharmacy unto itself". It has been claimed in traditional literature, to treat various kidney ailments due to its antioxidant potential. OBJECTIVE:To explore the possible mechanism of action of methanolic extract of P.granatum leaves (MPGL) in exerting a protective effect on gentamicin-induced nephropathy. MATERIAL AND METHODS:Animals were administered with gentamicin (80 mg/kg/day i.m.) and simultaneously with MPGL (100, 200 and 400 mg/kg p.o.) or metformin (100 mg/kg p.o.) for 8 days. A satellite group was employed in order to check f

SUBMITTER: Mestry SN 

PROVIDER: S-EPMC7125389 | biostudies-literature | 2020 Jan - Mar

REPOSITORIES: biostudies-literature