Expression of H₂S in Gestational Diabetes Mellitus and Correlation Analysis with Inflammatory Markers IL-6 and TNF-α.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is a severe threat to the health of both mother and child. The pathogenesis of GDM remains unclear, although much research has found that the levels of hydrogen sulfide (H₂S) play an important role in complications of pregnancy.

Methods

We collected venous blood samples from parturient women and umbilical vein blood (UVB) and peripheral venous blood (PVB) samples one hour after childbirth in the control, GDM-, and GDM+ groups in order to determine the concentration of glucose and H₂S in plasma; to measure levels of TNF-α, IL-1β, IL-6, TGF-β1, and ADP in parturient women and the UVB of newborns; and to find the correlation of H₂S with regression.

Results

We found that,

SUBMITTER: Teng Y 

PROVIDER: S-EPMC7125483 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature