Safety of antimicrobial de-escalation for culture-negative severe pneumonia.

ABSTRACT:

Purpose

This study investigated the outcomes of antimicrobial de-escalation (ADE) based on mortality and the incidence of multi-drug resistant (MDR) pathogen occurrence in patients with culture-negative pneumonia presenting with sepsis and septic shock.

Materials and methods

We retrospectively analyzed patients diagnosed with severe pneumonia requiring intensive care unit (ICU) admission and possessing negative microbiological culture results at a tertiary referral hospital in South Korea from March 2008 to July 2018.

Results

We identified 107 patients with culture-negative pneumonia. The Acute Physiologic and Chronic Health Evaluation (APACHE) II and Sepsis-related Organ Failure Assessment (SOFA) mean scores were 20.3 ± 8.6 and 9.6 ± 3.3, respectively. Among the pati

SUBMITTER: Byoung Soo K 

PROVIDER: S-EPMC7126337 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature