Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.

ABSTRACT: Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P(1) benzyl moiety led to improvements in ACE2 potency as well as to increased selectivity versus ACE and NEP.

SUBMITTER: Deaton DN 

PROVIDER: S-EPMC7126659 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature