Harnessing self-assembled peptide nanoparticles in epitope vaccine design.

ABSTRACT: Vaccination has been one of the most successful breakthroughs in medical history. In recent years, epitope-based subunit vaccines have been introduced as a safer alternative to traditional vaccines. However, they suffer from limited immunogenicity. Nanotechnology has shown value in solving this issue. Different kinds of nanovaccines have been employed, among which virus-like nanoparticles (VLPs) and self-assembled peptide nanoparticles (SAPNs) seem very promising. Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility. They also resemble pathogens in terms of their size. Their multivalency allows an orderly repetitive display of antigens on their surface, which induces a stronger immune respons

SUBMITTER: Negahdaripour M 

PROVIDER: S-EPMC7127164 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature