Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots.

ABSTRACT:

Unlabelled

ETHNOPHARMACOLOGICAL RELEVANCE SCUTELLARIA BAICALENSIS: Georgi (Labiatae) is a well-known traditional Chinese medicine to treat inflammation, cardiovascular diseases, respiratory and gastrointestinal infections, etc. The present study was to understand the metabolism of the root of Scutellaria baicalensis (a.k.a. Huangqin in Chinese) in the gastrointestinal tract and the correlation between the metabolites and their respective pharmacological activities.

Materials and methods

The water extract of the root of Scutellaria baicalensis (WESB) was incubated with simulated gastric and intestinal juices, and human fecal microflora for 24h at 37 °C. The HPLC-DAD analysis was used to monitor the in vitro metabolic process and identify its metabolites by comparing their abs

SUBMITTER: Xing S 

PROVIDER: S-EPMC7127269 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature