Effector CD8⁺ T cell-derived interleukin-10 enhances acute liver immunopathology.

ABSTRACT:

Background & aims

Besides secreting pro-inflammatory cytokines, chemokines and effector molecules, effector CD8⁺ T cells that arise upon acute infection with certain viruses have been shown to produce the regulatory cytokine interleukin (IL)-10 and, therefore, contain immunopathology. Whether the same occurs during acute hepatitis B virus (HBV) infection and role that IL-10 might play in liver disease is currently unknown.

Methods

Mouse models of acute HBV pathogenesis, as well as chimpanzees and patients acutely infected with HBV, were used to analyse the role of CD8⁺ T cell-derived IL-10 in liver immunopathology.

Results

Mouse HBV-specific effector CD8⁺ T cells produce significant amounts of IL-10 upon in vivo antigen encounter. This

SUBMITTER: Fioravanti J 

PROVIDER: S-EPMC7127652 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature