Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain.

ABSTRACT: Degenerative joint disease (DJD) associated-pain is a clinically relevant and common condition affecting domesticated cats and other species including humans. Identification of the neurobiological signature of pain is well developed in rodent pain models, however such information is lacking from animals or humans with naturally occurring painful conditions. In this study, identification of housekeeping genes (HKG) for neuronal tissue and expression levels of genes considered associated with chronic pain in rodent models were explored in cats with naturally occurring osteoarthritic pain. Fourteen adult cats were evaluated - seven without clinical signs of osteoarthritic pain, and seven with hind limb radiographic DJD and pain. Expression of an investigator-selected set of pain signaling gen

SUBMITTER: Ashwell M 

PROVIDER: S-EPMC7129418 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature