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Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak.

ABSTRACT: To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447-178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402-13.761; P = 0.011) were significantly associated with MERS-CoV infection.

SUBMITTER: Ko JH 

PROVIDER: S-EPMC7129617 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak.

Ko Jae-Hoon JH   Seok Hyeri H   Park Ga Eun GE   Lee Ji Yeon JY   Lee Ji Yong JY   Cho Sun Young SY   Ha Young Eun YE   Kang Ji-Man JM   Kim Yae-Jean YJ   Kang Cheol-In CI   Chung Doo Ryeon DR   Song Jae-Hoon JH   Peck Kyong Ran KR  

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20171206 2

To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. A total of 175 patients were closely exposed to a super-spreader, 26 of which were infected (14.9%). In a multivariate analysis, history of autologous stem cell transplantation (HR, 31.151; 95% CI, 5.447-178.145; P < 0.001) and tachypnea at ED (HR, 4.392; 95% CI, 1.402-13.76  ...[more]