Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome.

ABSTRACT:

Introduction

Disruption of metabolic function is a recognized feature of late onset Alzheimer's disease (LOAD). We sought to determine whether similar metabolic pathways are implicated in adults with Down syndrome (DS) who have increased risk for Alzheimer's disease (AD).

Methods

We examined peripheral blood from 292 participants with DS who completed baseline assessments in the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) using untargeted mass spectrometry (MS). Our sample included 38 individuals who met consensus criteria for AD (DS-AD), 43 who met criteria for mild cognitive impairment (DS-MCI), and 211 who were cognitively unaffected and stable (CS).

Results

We measured relative abundance of 8,805 features using MS and 180 putative metabolites were dif

SUBMITTER: Mapstone M 

PROVIDER: S-EPMC7131985 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature