Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.

ABSTRACT: Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified fatty acids (NEFA), the main substrate for synthesis of intrahepatic triglycerides (IHTG). To explore the underlying mechanism, we quantified hepatic mitochondrial fluxes and their regulators in humans by using positional isotopomer NMR tracer analysis. Ten overweight/obese subjects received stable isotope infusions of: [D₇]glucose, [¹³C₄]β-hydroxybutyrate and [3-¹³C]lactate before and after a 6-d KD. IHTG was determined by proton magnetic resonance spectroscopy (¹H-MRS). The KD diet decreased IHTG by 31% in the face of a 3% decr

SUBMITTER: Luukkonen PK 

PROVIDER: S-EPMC7132133 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature