Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6⁺B helper T cells in systemic lupus erythematosus.

ABSTRACT: Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4⁺CCR6⁺IL-7R⁺T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G (IgG) production. These tonsillar CCR6⁺B helper T cells were phenotypically distinct from follicular helper T (T_FH) cells and lacked BCL6 expression. In peripheral blood, a CCR6⁺T cell population with similar characteristics was identified, which lacked Th17- and T_FH-associated gene signatures and differentiation-associated surface markers. CD4⁺CCR6⁺T cells expressing IL-10, but not IL-17, were also dete

SUBMITTER: Facciotti F 

PROVIDER: S-EPMC7132288 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature