Evaluation of the 'ring sign' and the 'core sign' as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis.

ABSTRACT:

Background

Brain lesions with a hypointense ring or core were described in multiple sclerosis on susceptibility weighted imaging.

Objective

The purpose of this study was to study the evolution and prognostic relevance of susceptibility weighted imaging hypointense lesions in clinically isolated syndrome and early multiple sclerosis.

Methods

Sixty-six early multiple sclerosis and clinically isolated syndrome patients were followed over a median period of 2.9 years (range 1.6-4.6 years) and underwent 3T magnetic resonance imaging including 3D susceptibility weighted imaging and T2-weighted fluid-attenuated inversion recovery. We assessed the presence of susceptibility weighted imaging hypointense core or ring lesions, and Expanded Disability Status Scale at baseline and

SUBMITTER: Blindenbacher N 

PROVIDER: S-EPMC7132556 | biostudies-literature | 2020 Jan-Mar

REPOSITORIES: biostudies-literature