Coordination of cytoskeletal dynamics and cell behaviour during Drosophila abdominal morphogenesis.

ABSTRACT: During morphogenesis, cells exhibit various behaviours, such as migration and constriction, which need to be coordinated. How this is achieved remains elusive. During morphogenesis of the Drosophila adult abdominal epidermis, larval epithelial cells (LECs) migrate directedly before constricting apically and undergoing apoptosis. Here, we study the mechanisms underlying the transition from migration to constriction. We show that LECs possess a pulsatile apical actomyosin network, and that a change in network polarity correlates with behavioural change. Exploring the properties of the contractile network, we find that cell contractility, as determined by myosin activity, has an impact on the behaviour of the network, as well as on cytoskeletal architecture and cell behaviour. Pulsed contract

SUBMITTER: Pulido Companys P 

PROVIDER: S-EPMC7132776 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature