PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.

ABSTRACT: Signalling by target-derived neurotrophins is essential for the correct development of the nervous system and its maintenance throughout life. Several aspects concerning the lifecycle of neurotrophins and their receptors have been characterised over the years, including the formation, endocytosis and trafficking of signalling-competent ligand-receptor complexes. However, the molecular mechanisms directing the sorting of activated neurotrophin receptors are still elusive. Previously, our laboratory identified Bicaudal-D1 (BICD1), a dynein motor adaptor, as a key factor for lysosomal degradation of brain-derived neurotrophic factor (BDNF)-activated TrkB (also known as NTRK2) and p75^NTR (also known as NGFR) in motor neurons. Here, using a proteomics approach, we identified protein

SUBMITTER: Budzinska MI 

PROVIDER: S-EPMC7132798 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature