Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults.

ABSTRACT: Judgments of learning (JOL) pertain to introspective metamemory processes evaluating how well information is learned. Using a functional magnetic resonance imaging (fMRI) task, we investigated the neural substrates of JOL predictions in a group of 105 cognitively unimpaired older adults from the Harvard Aging Brain Study. Associations of JOL performance and its neural correlates with amyloid-β (Aβ) and tau pathology, two proteinopathies associated with Alzheimer's disease (AD) and aging, were also examined. We found that trials judged as learned well relative to trials judged as learned less well (high JOL > low JOL) engaged the ventromedial prefrontal cortex and precuneus, among other midline regions, in addition to bilateral hippocampi. In this cohort of older adults, greater levels of e

SUBMITTER: d'Oleire Uquillas F 

PROVIDER: S-EPMC7132950 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature