A qualitative transcriptional signature to reclassify histological grade of ER-positive breast cancer patients.

ABSTRACT:

Background

Histological grade (HG) is commonly adopted as a prognostic factor for ER-positive breast cancer patients. However, HG evaluation methods, such as the pathological Nottingham grading system, are highly subjective with only 50-85% inter-observer agreements. Specifically, the subjectivity in the pathological assignment of the intermediate grade (HG2) breast cancers, comprising of about half of breast cancer cases, results in uncertain disease outcomes prediction. Here, we developed a qualitative transcriptional signature, based on within-sample relative expression orderings (REOs) of gene pairs, to define HG1 and HG3 and reclassify pathologically-determined HG2 (denoted as pHG2) breast cancer patients.

Results

From the gene pairs with significantly stable REOs in pa

SUBMITTER: Li J 

PROVIDER: S-EPMC7132979 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature