E. coli diversity: low in colorectal cancer.

ABSTRACT:

Background

Escherichia coli are mostly commensals but also contain pathogenic lineages. It is largely unclear whether the commensal E. coli as the potential origins of pathogenic lineages may consist of monophyletic or polyphyletic populations, elucidation of which is expected to lead to novel insights into the associations of E. coli diversity with human health and diseases.

Methods

Using genomic sequencing and pulsed field gel electrophoresis (PFGE) techniques, we analyzed E. coli from the intestinal microbiota of three groups of healthy individuals, including preschool children, university students, and seniors of a longevity village, as well as colorectal cancer (CRC) patients, to probe the commensal E. coli populations for their diversity.

Results

We delineated t

SUBMITTER: Tang L 

PROVIDER: S-EPMC7133007 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature