AKT2 deficiency impairs formation of the BCR signalosome.

ABSTRACT:

Background

AKT2 is one of the key molecules that involves in the insulin-induced signaling and the development of cancer. In B cells, the function of AKT2 is unclear.

Methods

In this study, we used AKT2 knockout mice model to study the role of AKT2 in BCR signaling and B cell differentiation.

Results

AKT2 promotes the early activation of B cells by enhancing the BCR signaling and actin remodeling. B cells from AKT2 KO mice exhibited defective spreading and BCR clustering upon stimulation in vitro. Disruption of Btk-mediated signaling caused the impaired differentiation of germinal center B cells, and the serum levels of both sepecific IgM and IgG were decreased in the immunized AKT2 KO mice. In addition, the actin remodeling was affected due to the decreased level of

SUBMITTER: Du Z 

PROVIDER: S-EPMC7133013 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature