Weighted gene correlation network analysis reveals novel biomarkers associated with mesenchymal stromal cell differentiation in early phase.

ABSTRACT: Osteoporosis is a major public health problem that is associated with high morbidity and mortality, and its prevalence is increasing as the world's population ages. Therefore, understanding the molecular basis of the disease is becoming a high priority. In this regard, studies have shown that an imbalance in adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) is associated with osteoporosis. In this study, we conducted a Weighted Gene Co-Expression Network Analysis to identify gene modules associated with the differentiation of bone marrow MSCs. Gene Ontology and Kyoto Encyclopedia of Genes and Genome enrichment analysis showed that the most significant module, the brown module, was enriched with genes involved in cell cycle regulation, which is in line w

SUBMITTER: Xiao B 

PROVIDER: S-EPMC7134052 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature