Cumulative Blood Pressure Exposure During Young Adulthood and Mobility and Cognitive Function in Midlife.

ABSTRACT:

Background

High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by cerebral white matter hyperintensity (WMH) burden.

Methods

We included 191 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults), a community-based cohort of young individuals followed over 30 years. Cumulative BP was calculated as the area under the curve (mm Hg×years) from baseline up to year 30 examination. Gait and cognition were assessed at the year 30 examination. Cerebral WMH was available at year 30 in a subset of participa

SUBMITTER: Mahinrad S 

PROVIDER: S-EPMC7135652 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature