Remodeling of Zn²⁺ homeostasis upon differentiation of mammary epithelial cells.

ABSTRACT: Zinc is the second most abundant transition metal in humans and an essential nutrient required for growth and development of newborns. During lactation, mammary epithelial cells differentiate into a secretory phenotype, uptake zinc from blood circulation, and export it into mother's milk. At the cellular level, many zinc-dependent cellular processes, such as transcription, metabolism of nutrients, and proliferation are involved in the differentiation of mammary epithelial cells. Using mouse mammary epithelial cells as a model system, we investigated the remodeling of zinc homeostasis during differentiation induced by treatment with the lactogenic hormones cortisol and prolactin. RNA-Seq at different stages of differentiation revealed changes in global gene expression, including genes encod

SUBMITTER: Han Y 

PROVIDER: S-EPMC7135929 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature