Clinical prognostic model for older patients with advanced non-small cell lung cancer.

ABSTRACT:

Background

Older patients with non-small cell lung cancer (NSCLC) are often not prescribed standard therapy. It is important to know which older patients would be candidates for aggressive therapy based on their prognosis, and to develop a model that can help determine prognosis.

Methods

Data on older patients (≥70 years) enrolled on 38 NCI cooperative group trials of advanced NSCLC from 1991 to 2011 were analyzed. Multivariable Cox PH model was built with a stepwise selection. We derived a prognostic score using the estimated Cox PH regression coefficient. We then calculated the area under receiver operating characteristic (ROC) curve of survival in the testing set.

Results

The final analysis included 1467 patients, who were randomly divided into a training (n = 963)

SUBMITTER: Ganti AK 

PROVIDER: S-EPMC7136030 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature