Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study.

ABSTRACT:

Background

Ambient air pollution accelerates lung function decline among adults, however, there are limited data about its role in the development and progression of early stages of interstitial lung disease.

Aims

To evaluate associations of long-term exposure to traffic and ambient pollutants with odds of interstitial lung abnormalities (ILA) and progression of ILA on repeated imaging.

Methods

We ascertained ILA on chest CT obtained from 2618 Framingham participants from 2008 to 2011. Among 1846 participants who also completed a cardiac CT from 2002 to 2005, we determined interval ILA progression. We assigned distance from home address to major roadway, and the 5-year average of fine particulate matter (PM_2.5), elemental carbon (EC, a traffic-related PM

SUBMITTER: Rice MB 

PROVIDER: S-EPMC7136036 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature