APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort.

ABSTRACT:

Objective

To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD).

Method

The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern Alzheimer Disease Center Clinical Core; (2) 1,418 patients with autopsy-confirmed AD and amnestic dementia of the Alzheimer type (DAT/AD); and (3) 2,608 cognitively normal controls (NC). The latter 2 groups were compiled from the National Alzheimer Coordinating Center database. Logistic regression models analyzed the relationship between groups and APOE ε4 carrier status, adjusting for age at onset and sex as needed.

Results

Using NC

SUBMITTER: Weintraub S 

PROVIDER: S-EPMC7136069 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature