Applied precision cancer medicine in metastatic biliary tract cancer.

ABSTRACT:

Introduction

Advanced therapy-refractory biliary tract cancer (BTC) has poor prognosis and constitutes a major challenge for adequate treatment strategies. By mapping the molecular profiles of advanced BTC patients, precision cancer medicine may provide targeted therapies for these patients.

Objective

In this analysis, we aimed to show the potential of PCM in metastatic BTC.

Methods

In this single-center, real-world retrospective analysis of our PCM platform, we describe the molecular profiling of 30 patients diagnosed with different types of metastatic BTC. Tumor samples of the patients were examined using a 161-gene next-generation sequencing panel, immunohistochemistry (IHC), and fluorescence in situ hybridization for chromosomal translocations.

Results

In t

SUBMITTER: Taghizadeh H 

PROVIDER: S-EPMC7136181 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature