Membrane Adhesion via Glycolipids Occurs for Abundant Saccharide Chemistries.

ABSTRACT: Membrane-bound oligosaccharides with specific chemistries are known to promote tight adhesion between adjacent membranes via the formation of weak saccharide bonds. However, in the literature, one can find scattered evidence that other, more abundant saccharide chemistries exhibit similar behavior. Here, the influence of various glycolipids on the interaction between adjacent membranes is systematically investigated with the help of small- and wide-angle x-ray scattering and complementary neutron diffraction experiments. Added electrostatic repulsion between the membrane surfaces is used to identify the formation of saccharide bonds and to challenge their stability against tensile stress. Some of the saccharide headgroup types investigated are able to bind adjacent membranes together, but

SUBMITTER: Latza VM 

PROVIDER: S-EPMC7136278 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature