A Systematic Review of Renal Functional Reserve in Adult Living Kidney Donors.

ABSTRACT:

Introduction

The kidney's capacity to increase its glomerular filtration rate (GFR) in response to a higher functional demand is known as the renal functional reserve (RFR). Good short-term outcomes after living kidney donation have led to more acceptance of borderline donors (with hypertension, obesity, older age) due the ongoing shortage of donor organs. Given recent concerns about increased long-term risk in some donor subgroups, better donor stratification is needed. Measurement of RFR could inform assessment of donor risk.

Methods

A systematic literature review of studies that assessed RFR in donors pre- and/or post-donation was performed. Given study heterogeneity, descriptive analysis and narrative synthesis was conducted.

Results

Sixteen of 3250 identified stu

SUBMITTER: Figurek A 

PROVIDER: S-EPMC7136324 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature