9p21.3 coronary artery disease risk locus and interferon alpha 21: Association study in an Asian Indian population.

ABSTRACT:

Introduction

Type I Interferons (INFαs and INF β) are known to be proinflammatory cytokines that promote atherosclerosis. IFNA21 is a member of alpha Interferon gene cluster on short arm of chromosome 9. We analyzed the potential link between 9p21 coronary artery disease (CAD) risk locus and IFNA21.

Objectives

a) study of association between serum IFNA21 levels and 14 demographic/clinical variables, including age, gender, diabetes, hypertension, and duration of CAD, b) study of association between high serum IFNA21 levels and 30 9p21 SNP genotypes.

Methods

To estimate serum circulating levels of IFNA21, we performed sandwich ELISA in 184 controls and 167 CAD cases. The IFNA21 levels could be classified into two broad classes: a) Low-level group: ≤15.6 pg/ml b) High-le

SUBMITTER: Kalpana B 

PROVIDER: S-EPMC7136328 | biostudies-literature | 2019 Nov - Dec

REPOSITORIES: biostudies-literature