Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model.

ABSTRACT: Biological tissues contain micrometer-scale gaps and pores, including those found within extracellular matrix fiber networks, between tightly packed cells, and between blood vessels or nerve bundles and their associated basement membranes. These spaces restrict cell motion to a single-spatial dimension (1D), a feature that is not captured in traditional in vitro cell migration assays performed on flat, unconfined two-dimensional (2D) substrates. Mechanical confinement can variably influence cell migration behaviors, and it is presently unclear whether the mechanisms used for migration in 2D unconfined environments are relevant in 1D confined environments. Here, we assessed whether a cell migration simulator and associated parameters previously measured for cells on 2D unconfined compliant

SUBMITTER: Prahl LS 

PROVIDER: S-EPMC7136340 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature