A Systematic Review of Prophylactic Anticoagulation in Nephrotic Syndrome.

ABSTRACT:

Introduction

Nephrotic syndrome is associated with an increased risk of venous and arterial thromboembolism, which can be as high as 40% depending on the severity and underlying cause of nephrotic syndrome. The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend prophylactic anticoagulation only in idiopathic membranous nephropathy but acknowledge that existing data are limited and of low quality. There is a need for better identification of vulnerable patients in order to balance the risks of anticoagulation.

Methods

We undertook a systematic search of the topic in MEDLINE, EMBASE and COCHRANE databases, for relevant articles between 1990 and 2019.

Results

A total of 2381 articles were screened, with 51 full-text articles reviewed. In all, 28

SUBMITTER: Lin R 

PROVIDER: S-EPMC7136344 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature